Dongoh Lee, PhD

Postdoctoral Research Scholar
Biography
Dongoh's major research area is ion transport in excitable cells and non-excitable cells. Voltage is regarded as a determinant of ion flow through ion channels and its magnitude is proportional to ion channel conductance. Voltage establishment across the membrane can be estimated using Goldman-Hodgkin-Katz (GHK) equation voltage equation. Simple assumption of constant electric field, ion concentration, and neglecting convection derives the GHK equation from Nernst-Planck. These equations can predict and explain ion flux, with some restrictions. This is because charge near the solid-liquid interface provides zeta-potential and capacitance which are regarded as crucial contributing factors to ion flux. Since epithelial ion transport can be represented with passive electrical components, circuit analysis or electrochemical impedance spectroscopy can further provide details of individual component properties. He studied chloride and bicarbonate conductance in CFTR and addressed anion conductance and capacitance in pig vas deferens cells. As a side project, he programmed neuronal action potential incorporating chloride channel which can hyperpolarize or repolarize the membrane potential depending on intracellular chloride concentration, as seen in infant vs adult and monovalent cation channel to initiate the action potential stimulated by acetylcholine. 
In free time, he spends the time with family or plays musical instruments.
Dongoh-Lee.png
Education
PhD Kansas State University
DVM Chungbuk National University
MS Chungbuk National University